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References

  1. Hadzic A. Hadzic’s Textbook of Regional Anesthesia and Acute Pain Management. 2nd ed. Mcgraw-Hill; 2017. 
     

  2. Mohamed SA, Hussam AM, Abdallah SA, Sarhan KA, Shaban AM. Ondansetron is an effective alternative to decrease the incidence of postspinal hypotension in healthy subjects undergoing infra-umbilical surgeries compared to combined volume loading and vasoconstrictors: randomized controlled trial. Open Access Maced J Med Sci. 2018;6(12):2363. doi:10.3889/oamjms.2018.491 
     

  3. Nath S, Aggarwal N, Saha A, Srivatsava A. Prophylactic efficacy of intravenous ondansetron in prevention of spinal anaesthesia induced hypotension: randomized, double blinded, placebo controlled study. Int J Health Sci. 2022; 6(S8):3142-3153. doi:10.53730/ijhs.v6nS8.1280 

  4. Baig R, Shah AA, Khurshid T, Abid L, Tariq Z. Use of ondansetron for prevention of spinal induced hypotension. JIMDC. 2017; 6(4):208-213. Accessed March 5, 2023. https://jimdc.org.pk/index.php/JIMDC/article/view/96 
     

  5. Flood P, Rathmell J. Stoelting’s Pharmacology &Physiology in Anesthetic Practice. 6th ed. Wolters Kluwer; 2020. 
     

  6. Hou X-M, Chen Y-J, Lai L, Liu K, Shen Q-H. Ondansetron reduces the incidence of hypotension after spinal anaesthesia: a systematic review and meta-analysis. Pharmaceuticals. 2022; 15(12):1588. doi:10.3390/ph15121588 
     

  7. Tubog TD. Kane TD, Pugh MA. Effects of ondansetron on attenuating spinal anesthesia-induced hypotension and bradycardia in obstetric and nonobstetric subjects: a systematic review and meta-analysis. AANA J. 2017;85(2):113-122. PMID: 30501160 
     

  8. Owczuk R, Wenski W, Twardowski P, et al. Ondansetron attenuates the decrease in blood pressure due to spinal anesthesia in the elderly: a double blind, placebo-controlled study. Minerva Anestesiol. 2015;81(6):598-607. PMID: 25220555 
     

  9. Marashi SM, Soltani-Omid S, Mohammadi SS, Aghajani Y, Movafegh A. Comparing two different doses of intravenous ondansetron with placebo on attenuation of spinal-induced hypotension and shivering. Anesth Pain Med. 2014;4(2):e12055. doi:10.5812/aapm.12055 
     

  10. Mendonca FT, Crepaldi LC, Gersanti RC, de Araújo KC. Effect of ondansetron on spinal anesthesia-induced hypotension in non-obstetric surgeries: a randomized, double-blind and placebo-controlled trial. Braz J Anesthesiol. 2021;71(3):233-240. doi:10.1016/j.bjane.2020.12.028 
     

  11. Ortiz-Gomez JR, Palacio-Abizanda FJ, Morillas-Ramirez F, Fornet-Ruiz I, Lorenzo-Jiménez A, Bermejo-Albares ML. Reducing by 50% the incidence of maternal hypotension during elective caesarean delivery under spinal anesthesia: effect of prophylactic ondansetron and/or continuous infusion of phenylephrine – a double-blind, randomized, placebo controlled trial. Saudi J Anaesth. 2017;11(4):408-414. doi:10.4103/sja.SJA_237_17 
     

  12. Potdar MP, Kamat LL, Jha TR, Talnikar AS, Mahevi ZM. Effect of ondansetron in attenuation of post-spinal hypotension in caesarean section: a comparison of two different doses with placebo. J Obstet Anaesth Crit Care. 2017;7(2):69-74. doi:10.4103/joacc.JOACC_7_16 
     

  13. Khalifa OSM. A comparative study of prophylactic intravenous granisetron, ondansetron, and ephedrine in attenuating hypotension and its effect on motor and sensory block in elective cesarean section under spinal anesthesia. Ain Shams J Anesthesiol. 2015;8:166-172. doi:10.4103/1687-7934.156667 
     

  14. Sleman SI, Refki MA, Abaza KAGE, Elsayed MI. Cardiovascular effects associated with use of prophylactic intravenous ondansetron in patients undergoing orthopedic surgeries under spinal anesthesia. Eur J Mol Clin Med. 2021;8(3):4238-4249. Accessed March 5, 2023. https://www.ejmcm.com/article_15334.html 
     

  15. Rashad MM, Farmawy MS. Effects of intravenous ondansetron and granisetron on hemodynamic changes and motor and sensory blockade induced by spinal anesthesia in parturients undergoing cesarean section. Egypt J Anaesth. 2013;29(4)369-374. doi:10.1016/j.egja.2013.04.004 
     

  16. Attri A, Sharma N, Singh M, Bansal K, Singh S. Effect of intravenous ondansetron on maternal hemodynamics during elective caesarean section under subarachnoid block. J Obstet Anaesth Crit Care. 2019;9(2):94-98. doi:10.4103/joacc.JOACC_27_19 
     

  17. Raghu K, Kumar S, Rajaram G, Nikhil N, Damodar P. Effect of ondansetron in the prevention of spinal anesthesia-induced hypotension. J Sci Soc. 2018;45(3):125-128. doi:10.4103/jss.JSS_45_18 
     

  18. Sahoo T, SenDasgupta C, Goswami A, Hazra A. Reduction in spinal-induced hypotension with ondansetron in parturients undergoing caesarean section: a double-blind randomised, placebo-controlled study. Int J Obstet Anesth. 2012; 21(1):24-28. doi:10.1016/j.ijoa.2011.08.002 
     

  19. Mostafa AA, Attia ZM, el Moniem OA, Mohamed R. Intravenous ondansetron versus granisetron on hemodynamic changes induced by spinal anesthesia in elderly patients undergoing lower limb surgeries. J Cardiovasc Dis Res. 2021;12(3):2031-2038. doi:10.31838/jcdr.2021.12.03.257 
     

  20. Abd-Allah MYY, Abo-El Wafa AMA, Zaghloul AA, El Bahnasawy NSE. The effect of different doses of ondansetron in prevention of hypotension and shivering in patients undergoing lower limb surgery under spinal anesthesia. Med J Cairo Univ. 2021;89(7):3029-3038. doi:10.21608/mjcu.2021.225300 
     

  21. Pellegrini JE, Nagelhout J, Elisha S. Regional Anesthesia: Spinal and Epidural Anesthesia. In: Nurse Anesthesia. 6th ed. Elsevier; 2018:1015-1041. 
     

  22. Hou X-M, Chen Y-J, Lai L, Liu K, Shen Q-H. Ondansetron reduces the incidence of hypotension after spinal anaesthesia: a systematic review and meta-analysis. Pharmaceuticals. 2022;15(12):1588. doi:10.3390/ph15121588 
     

  23. Tatikonda CM, Rajappa GC, Rath P, Abbas M, Madhapura VS, Gopal NV. Effect of intravenous ondansetron on spinal anesthesia-induced hypotension and bradycardia: a randomized controlled double-blinded study. Anesth Essays Res. 2019;13(2):340-346. doi:10.4103/aer.AER_22_19 
     

  24. Zhou C, Zhu Y, Bao Z, Wang X, Liu Q. Efficacy of ondansetron for spinal anesthesia during cesarean section: a meta-analysis of randomized trials. J Int Med Res. 2018;46(2):654-662. doi:10.1177/0300060517716502 
     

  25. Gao L, Zheng G, Han J, Wang Y, Zheng J. Effects of prophylactic ondansetron on spinal anesthesia-induced hypotension: a meta-analysis. Int J Obstet Anesth. 2015;24(4):335-43. doi:10.1016/j.ijoa.2015.08.012
     

  26. Terkawi AS, Tiouririne M, Mehta SH, Hackworth JM, Tsang S, Durieux, ME. Ondansetron does not attenuate hemodynamic changes in patients undergoing elective cesarean delivery using subarachnoid anesthesia: a double-blind, placebo-controlled, randomized trial. Reg Anesth Pain Med. 2015;40(4):344-348. doi:10.1097/01.aoa.0000482615.33162.f6 
     

  27. Mohamed S, Befkadu A, Mohammed A, et al. Effectiveness of prophylactic ondansetron in preventing spinal anesthesia induced hypotension and bradycardia in pregnant mother undergoing elective cesarean delivery: a double blinded randomized control trial. Int J Surg Open. 2021; 35:100401. doi:10.1016/j.ijso.2021.100401 
     

  28. Oofuvong M, Kunapaisal T, Karnjanawanichkul O, Dilokrattanaphijit N, Leeratiwong, J. Minimal effective weight-based dosing of ondansetron to reduce hypotension in cesarean section under spinal anesthesia: a randomized controlled superiority trial. BMC Anesthesiol. 2018;18:105. doi:10.1186/s12871-018-0568-7 
     

  29. Ruttala NSS, Seelam P, Mallik NVK, Thummala V. Hospital based study to know the effectiveness of ondansetron over spinal anesthesia induced hypotension & bradycardia. Eur J Mol Clin Med. 2022;9(2):1869-1878. Accessed March 5, 2023. https://ejmcm.com/article_18267.html 
     

  30. Campagna JA, Carter C. Clinical relevance of the Bezold–Jarisch reflex. Anesthesiology. 2003;98(5):1250-1260. doi:10.1097/00000542-200305000-00030 
     

  31. Melnyk B, Fineout-Overholt E. Evidence-Based Practice in Nursing & Healthcare: A Guide to Best Practice. 4th ed. Wolters Kluwer; 2019. 
     

  32. Abbas N, Shah SAR, Naqvi SS. Role of prophylactic ondansetron for prevention of spinal anaesthesia induced hypotension in lower segment caesarean section. Pak Armed Forces Med J. 2016;66(6)790-794. Accessed March 5, 2023. https://pafmj.org/index.php/PAFMJ/article/view/927 

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